ABL is a global leader in immunomonitoring, offering expert biomarker testing services to advance therapies from discovery to clinical stages.
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What do all therapies under development have in common?
Whether in preclinical or clinical stage, they all need robust and reliable biomarker monitoring tools to track and characterize their biological effect.
ABL services address most critical requirements:
Sampling plans and logistics
Assay development and validation
Integrated approach to utilizing multiple instrument platforms
Efficient study execution and data analysis
Flexible options for alternative study approaches
Measuring the impact of a drug on the functionality of immune cells generally relies on peripheral blood mononuclear cells (PBMC). Preserving their viability and, most importantly, their functional integrity is critical for generating reliable, unbiased data. In order to ensure sample preservation, ABL has developed a network of international laboratories for timely (<8H) and high quality PBMC processing & storage using harmonized SOPs. This network is supporting several multi-site clinical trials in Europe and North America.
We support dozens of preclinical and clinical studies evaluating the safety and efficacy of several immunotherapies, including monoclonal antibodies (MAbs), Antibody Drug conjugates (ADCs), therapeutic vaccines, Chimeric Antigen Receptor T cells (CAR-T cells), oncolytic virotherapies, etc.
Autoimmunity / Inflammation
ABL Lyon is certified according to ISO 9001:2008 standards since October 2011.
In addition to the ISO standards, our QMS is based on Good Laboratory Practices (as revised in 1997 issued by the OCDE), and uses the following referential as guidance:
- SecureRaw data availability
- Total confidentiality
- Timely troubleshooting report
- Questioning unexpected results
- Scientific expertise
- Understand and Qualify the need
- Offier the most relevant methods
- Optimize, validate methods
- Explore new Approaches
- Full study report
- Critical analysis of generated data
- Secured archiving of study results
- GCLP / ISO 9001:2008/2015
- Secure system
- Sample management
- Stringent QCs criteria
- Equipment maintenance
- Full traceability
Wherever you are in your product development pipeline, ABL has established protocols and trained personnel for rapid study set-up at facilities located in the U.S. and Europe.
We can either transfer your method to our labs or our team can work with you to adapt or develop a novel suitable method. In most cases, samples can be assayed on fresh or frozen samples and the results provided to you in a preferred format.